Diagnosis and Management of Focal Liver Lesions

Jorge A. Marrero, MD,1 Joseph Ahn, MD, FACG,2 K. Rajender Reddy, MD, FACG3

1University of Texas at Southwestern, Dallas, Texas, USA; 2Oregon Health and Science University, Portland, Oregon, USA; 3University of Pennsylvania, Philadelphia, Pennsylvania, USA

Am J Gastroenterol advance online publication 19 August 2014; doi: 10.1038/ajg.2014.213
Received 15 November 2013; Accepted 22 May 2014
Advance online publication 19 August 2014

Correspondence: K. Rajender Reddy, MD, FACG, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA E-mail: rajender.reddy@uphs.upenn.edu


Focal liver lesions (FLL) have been a common reason for consultation faced by gastroenterologists and hepatologists. The increasing and widespread use of imaging studies has led to an increase in detection of incidental FLL. It is important to consider not only malignant liver lesions, but also benign solid and cystic liver lesions such as hemangioma, focal nodular hyperplasia, hepatocellular adenoma, and hepatic cysts, in the differential diagnosis. In this ACG practice guideline, the authors provide an evidence-based approach to the diagnosis and management of FLL.

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